Psychostimulants may cause restlessness, agitation, insomnia, nightmares, psychosis, anorexia; and may exacerbate preexisting cardiac disease.
Psychostimulants should be administered early in a patient's daily waking cycle. Contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate-severe hypertension, and glaucoma. Hypertension; may decrease the convulsive threshold in patients with a history of seizure disorders.
EKG at baseline to evaluate for preexisting cardiac conduction abnormalities.
Therapeutic drug concentration ranges in plasma have been identified for all agents, but dosage adjustments should be based on a patient's clinical response and not solely on plasma concentrations.
Produces mild inhibition of and may interact with drugs metabolized by cytochrome P450 CYP2D6 isozymes with little, if any, effect on CYP1A2, CYP2C9/10, CYP2C19, or CYP3A3/4.
Alprazolam (Xanax) and other benzodiazepines are used to treat anxiety disorders / panic attacked.
Side effets may include drowsiness, headache, irritability, dry mouth, increased salivation, ligh-headedness, tiredness, dizziness, difficulty concentrating, nausea, constipation, changes in sex drive, joint pain, difficulty uriniating, and weight changes.
Fluoxetine probably inhibits CYP2C9/10, moderately inhibits CYP2C19, and mildly inhibits CYP3A4; fluoxetine metabolism is impaired in elderly patients.