You've Got Mail once again paired Ryan with Hanks, earning her a third Golden Globe nomination and making over 0 million worldwide.
She also appeared in 1998's Hurlyburly with Sean Penn.
In 1986, she played Carole Bradshaw, the wife of Naval Flight Officer Nick "Goose" Bradshaw (played by Anthony Edwards) in Top Gun. (1989), which paired her with comedic leading man Billy Crystal and earned her a Golden Globe nomination.
Ryan appeared in the film Innerspace (1987) with her future husband Dennis Quaid, and later in the remake of D. Her portrayal of Sally Albright includes an oft-recounted scene in which her character, lunching with Crystal in Katz's Delicatessen in Manhattan, theatrically demonstrates for him how easy it is for a woman to fake an orgasm.
(1989) brought her widespread attention and her first Golden Globe nomination.
Ryan subsequently established herself, both nationally and internationally, as one of the most successful actresses in the 1990s and early 2000s, particularly in romantic comedy films such as Sleepless in Seattle (1993), French Kiss (1995), You've Got Mail (1998), and Kate & Leopold (2001).
She also appeared opposite Matthew Broderick in Addicted to Love playing a female lead at least superficially different than her usual direction, as one of a pair of jilted lovers bent on revenge. City of Angels drew positive reviews and became a financial success, topping nearly 0 million worldwide.
Due to her success as an actress, she dropped out of college a semester before she planned to graduate.
After her film debut in George Cukor's Rich and Famous, Ryan played Betsy Stewart in the daytime drama As the World Turns, from 1982 to 1984, and her character was featured in a popular romantic story arc.
Released to mixed reviews by critics, Ryan's first film release of 2008 was The Deal, a satirical comedy film based on Peter Lefcourt's 1991 novel of the same title about Hollywood.
Directed by Steven Schachter and co-starring William H.Her other films include The Doors (1991), When a Man Loves a Woman (1994), Courage Under Fire (1996), Addicted to Love (1997), City of Angels (1998), Proof of Life (2000), and The Women (2008). She has two sisters, Dana and Annie, and a brother, musician Andrew Hyra, a member of the band Billy Pilgrim.