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An ampoule, allegedly dating back to the year 305 and filled with the blood of Saint Januarius (San Gennaro), bishop of Benevento, has been kept for centuries in the Cathedral at Naples.

Every year on 19 September the town celebrates the Feast of San Gennaro, when the solid reddish-brown contents of the ampoule usually liquifies after being taken out of a safe, carried in procession and placed on the Cathedral's altar.

Modern ampoules are most commonly used to contain pharmaceuticals and chemicals that must be protected from air and contaminants.

They are hermetically sealed by melting the thin top with an open flame, and usually opened by snapping off the neck.

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Modern glass ampoules are produced industrially from short lengths of glass tubing, shaped by heating with gas torches and gravity in automated production lines.If properly done, this last operation creates a clean break without any extra glass shards or slivers; but the liquid or solution may be filtered for greater assurance.

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